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Browsing by Subject "axon guidance"
Now showing items 1-7 of 7
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Ascending midbrain dopaminergic axons require descending GAD65 axon fascicles for normal pathfinding
(2014)The Nigrostriatal pathway (NSP) is formed by dopaminergic axons that project from the ventral midbrain to the dorsolateral striatum as part of the medial forebrain bundle. Previous studies have implicated chemotropic ... -
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Axon guidance, behavior and learning: The quest from Netrin to the brain
(2011)Axon guidance is fundamental to the initial organization of the brain, and as a result, the organization of behavior and learning in the mature animal. The impressive plasticity inherent in complex nervous systems allows ... -
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Balancing growth and repulsion: Slit proteolysis generates diverse signals in axon guidance
(2021)The nervous system gathers and interprets information from the environment and can generate a physiological response. Interpreting environmental stimuli requires communication between the surface of the body and the brain ... -
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Development of the Oculomotor Nerve: A Role for Slit Signaling
(2014)The ability to visually locate and follow objects of interest relies on ocular motor systems that control eye movements. The ocular motor system includes motor neurons located in the CNS that innervate the extraocular ... -
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Elav-Mediated Exon Skipping and Alternative Polyadenylation of the Dscam1 Gene Are Required for Axon Outgrowth
(2019)Many metazoan genes express alternative long 3' UTR isoforms in the nervous system, but their functions remain largely unclear. In Drosophila melanogaster, the Dscam1 gene generates short and long (Dscam1-L) 3' UTR isoforms ... -
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Netrin1-DCC-Mediated Attraction Guides Post-Crossing Commissural Axons in the Hindbrain
(2015)Commissural axons grow along precise trajectories that are guided by several cues secreted from the ventral midline. After initial attraction to the floor plate using Netrin1 activation of its main attractive receptor, DCC ... -
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The Role of Apoptotic Signaling in Axon Guidance
(2018)Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level ...