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Browsing by Subject "nitric oxide"
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Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties
(2018)Preterm birth before 37 weeks of completed gestation results in numerous health consequences for the foetus. Preterm labour leads to preterm birth in over 50% of cases, and no FDA-approved treatment can prevent labour or ... -
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Inhibitory Neural Regulation of the Ca2+ Transients in Intramuscular Interstitial Cells of Cajal in the Small Intestine
(2018)Gastrointestinal motility is coordinated by enteric neurons. Both inhibitory and excitatory motor neurons innervate the syncytium consisting of smooth muscle cells (SMCs) interstitial cells of Cajal (ICC) and PDGFR alpha(+) ... -
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Intimations on the Pathophysiology of Human Preterm Labor: The Unique Actions of Nitric Oxide in the Myometrium and the Consequences of its Dysregulation
(2017)Approximately 12% of all infants are born prematurely in the United States, costing in excess of 26 billion dollars annually. About half of those preterm births are the result of spontaneous preterm labor (sPTL), which is ... -
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The human uterine smooth muscle S-nitrosoproteome fingerprint in pregnancy, labor, and preterm labor.
(10/15/2013)Molecular mechanisms involved in uterine quiescence during gestation and those responsible for induction of labor at term are incompletely known. More than 10% of babies born worldwide are premature and 1,000,000 die ... -
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The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy
(2017)S-nitrosoglutathione reductase (GSNOR), or ADH5, is an enzyme in the alcohol dehydrogenase (ADH) family. It is unique when compared to other ADH enzymes in that primary short-chain alcohols are not its principle substrate. ...