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Author | Desai, Rupak | |
Author | Parekh, Tarang | |
Author | Goyal, Hemant | |
Author | Fong, Hee K. | |
Author | Zalavadia, Dipen | |
Author | Damarlapally, Nanush | |
Author | Doshi, Rajkumar | |
Author | Savani, Sejal | |
Author | Kumar, Gautam | |
Author | Sachdeva, Rajesh | |
Date Accessioned | 2019-09-24T15:39:31Z | |
Date Available | 2019-09-24T15:39:31Z | |
Date of Issue | 2019 | |
Identifier (Citation) | Desai, R., Parekh, T., Goyal, H., Fong, H. K., Zalavadia, D., Damarlapally, N., … Sachdeva, R. (2019). Impact of gout on in-hospital outcomes of acute coronary syndrome-related hospitalizations and revascularizations: Insights from the national inpatient sample. World Journal of Cardiology, 11(5), 137–148. doi:10.4330/wjc.v11.i5.137 | |
ISSN | 1949-8462 | |
Identifier (URI) | http://hdl.handle.net/11714/6244 | |
Description | Previous studies have established a role of gout in predicting risk and prognosis of cardiovascular diseases. However, large-scale data on the impact of gout on inpatient outcomes of acute coronary syndrome (ACS)-related hospitalizations and post-revascularization is inadequate. AIM To evaluate the impact of gout on in-hospital outcomes of ACS hospitalizations, subsequent healthcare burden and predictors of post-revascularization inpatient mortality. METHODS We used the national inpatient sample (2010-2014) to identify the ACS and gout-related hospitalizations, relevant comorbidities, revascularization and post-revascularization outcomes using the ICD-9 CM codes. A multivariable analysis was performed to evaluate the predictors of post-revascularization in-hospital mortality. RESULTS We identified 3144744 ACS-related hospitalizations, of which 105198 (3.35%) also had gout. The ACS-gout cohort were more often older white males with a higher prevalence of comorbidities. Coronary artery bypass grafting was required more often in the ACS-gout cohort. Post-revascularization complications including cardiac (3.2% vs 2.9%), respiratory (3.5% vs 2.9%), and hemorrhage (3.1% vs 2.7%) were higher whereas all-cause mortality was lower (2.2% vs 3.0%) in the ACS-gout cohort (P < 0.001). An older age (OR 15.63, CI: 5.51-44.39), non-elective admissions (OR 2.00, CI: 1.44-2.79), lower household income (OR 1.44, CI: 1.17-1.78), and comorbid conditions predicted higher mortality in ACS-gout cohort undergoing revascularization (P < 0.001). Odds of post-revascularization inhospital mortality were lower in Hispanics (OR 0.45, CI: 0.31-0.67) and Asians (OR 0.65, CI: 0.45-0.94) as compared to white (P < 0.001). However, post-operative complications significantly raised mortality odds. Mean length of stay, transfer to other facilities, and hospital charges were higher in the ACS-gout cohort. CONCLUSION Although gout was not independently associated with an increased risk of post-revascularization in-hospital mortality in ACS, it did increase post-revascularization complications. | |
Item Format | ||
Rights | Creative Commons Attribution-NonCommercial 4.0 International | |
Rights URL | http://creativecommons.org/licenses/by-nc/4.0 | |
Source URI | https://www.wjgnet.com/1949-8462/full/v11/i5/137.htm | |
Subject | Acute coronary syndrome
| |
Subject | Serum uric acid
| |
Subject | acute myocardial-infarction
| |
Subject | heart-disease
| |
Subject | risk-factor
| |
Subject | hyperuricemia
| |
Subject | all-cause
| |
Subject | cardiovascular mortality
| |
Subject | Coronary artery bypass grafting
| |
Subject | global registry
| |
Subject | Gout
| |
Subject | In-hospital outcomes
| |
Subject | independent impact
| |
Subject | Myocardial infarction
| |
Subject | no-reflow phenomenon
| |
Subject | Percutaneous coronary intervention
| |
Subject | Revascularization
| |
Subject | serum uric-acid
| |
Subject | Unstable angina
| |
Title | Impact of gout on in-hospital outcomes of acute coronary syndrome-related hospitalizations and revascularizations: Insights from the national inpatient sample | |
Type | Article | |
Rights Holder | Authors | |
Department | Department of Internal Medicine | |
Identifier (DOI) | 10.4330/wjc.v11.i5.137 | |
Journal Title | World Journal of Cardiology |